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A chiral hplc assay for the separation of the four stereoisomers of labetalol in biological fluids was developed.The limit of detection of the individual isomers was 0.6 ng of injected racemic labetalol.In maternal plasma the concentration of the rr isomer was 2512 higher than those of the sr, ss and rs isomers throughout the infusion and post infusion period.The rr isomer had.
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